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Rhythm anticipates screening the first patient for this 26-week open-label trial of RM-718 in December 2025

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Specifically, reduced expression and phosphorylation of ERK1/2, JNK1, and P38 MAPK were observed, along with decreased expression of pro-angiogenic factors (VEGF), fibroblast growth factor receptors (FGFR-1), transforming growth factor 1 (TGF-1), Snail, and hypoxia-inducible factor 1 (HIF-1)