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Townsend DM, Manevich Y, He L et al (2008) Novel role for glutathione S-transferase

Aging results in various changes, including a decline in notochordal cells, the decline in vascularity, a decrease in proteoglycan synthesis and accumulation of degradation end products all of which cumulatively disrupt the homeostasis within the IVD

Extra virgin olive oil, zinc, and iron may also provide benefits in reducing ROS, followed by diminished cardiovascular risks in FM subjects

It will be a major achievement to unravel those mechanisms and to steer these such that therapeutic targeting is most beneficial

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