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Discontinuation and weight regain How often people stop the medication TRIUMPH-4 (n=445, 68 weeks, obesity with knee osteoarthritis): 18.2% on 12 mg, 12.2% on 9 mg, 4% on placebo 2 TRANSCEND-T2D-1 (n=537, 40 weeks, type 2 diabetes): 5.1% on 12 mg, 4.5% on 9 mg, 0% on placebo 3 Phase 2 (n=338, 48 weeks): 6 to 16% across doses, 1% on placebo 1 For comparison, Wegovys STEP-1 trial reported a discontinuation rate of around 7% due to side effects, and Mounjaros SURMOUNT-1 reported a similar rate

B12 is safe for most, but interactions should be reviewed

How to Rotate Effectively You do not necessarily need to switch from your stomach to your thigh every week, although you can

Healthy Fats Monounsaturated and unsaturated fats may enhance the bodys GLP-1 response

In the same manner, one person might handle the side effects of Mounjaro better than those of Wegovy, or vice versa