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Importantly, although GLP-1(2836)driven ATP generation was retained in caSMCs isolated from sAC / mice (Figure 4C), cells lacking sAC could not generate cAMP in response to this stimulus (Figure 4D)

Although these compounds displayed lower activity than conventional drugs like Vildagliptin and Sitagliptin, two of the newly synthesized compounds showed potential DPP-4 inhibitory effects at a concentration of 10 M

Curr Pharm Des 31(37):29592971

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