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December 4, 2023

More commonly, DPP-4 inhibitors are recommended as an option at second-line or third-line therapy in combination with metformin, when blood glucose remains inadequately controlled

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These systems face criticism regarding environmental issues (environmental pollution, soil erosion, biodiversity collapse, deforestation), spatial concerns (increased cultivated land area, land grabbing), economic challenges (poverty, dependence on chemical inputs, price volatility, low farmer incomes), social problems (hunger, land conflicts, loss of traditional knowledge), and sanitary risks (animal production sanitary crises, pesticide exposure) (Gasselin et al