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Based on our data, I would advise exercising particular caution when prescribing GLP-1 RAs to older [diabetic] patients or those with a history of stroke, as both groups were found to have an even higher risk of developing [the condition]. In an accompanying editorial, Brian VanderBeek, an associate professor of ophthalmology at the Hospital of the University of Pennsylvania, said the findings suggested that large numbers of patients could be affected
transitioning to monthly maintenance dosing at that point preserves most of the metabolic benefit while reducing treatment burden
But semaglutide is generally, as they say, well tolerated. True believers see a panacea: a treatment for alcoholism, heart disease, polycystic ovary syndrome, Alzheimers, Parkinsons, sleep apnea, liver disease, and a newly identified mental obsession with eating and dieting known as food noise, which is especially common in the US
Diabetes Care (2021) 44(1):2906
MHRA Drug Safety Update: Semaglutide and risk of non-arteritic anterior ischaemic optic neuropathy
