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ADA Recommendations for GLP-1 RA in T2DM Patients The GLP-1 receptor agonists, with or without metformin based on glycemic needs, are appropriate initial therapy for patients with type 2 diabetes mellitus (T2DM) with or at high risk for atherosclerotic cardiovascular disease (ASCVD)/indicators of high-risk, heart failure (HF), or chronic kidney disease (CKD)

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Moreover, our study revealed that GLP-1 analogs, including GLP-1, liraglutide, and exendin-4, along with the GLP-1 antagonist exendin 939, derived from exendin-4, which shares 53% sequence homology with native GLP-1 39 , effectively inhibited CAP-induced TRPV1 activation in mouse DRG neurons