Mechanisms affecting BBB to neurodegeneration Neurodegenerative diseases such as AD, PD, ALS, and MS, while distinct in clinical presentation, share a convergence on impaired BBB stability, CBF reduction, and vascular inflammation, reflecting parallel paths of progressive neurodegeneration distinct from acute brain injuries
That said, while the therapeutic potential is massive, the clinical trials for newer peptides are still in early phases
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It suffers from bioavailability issues, and the CNS-targeting theory remains unvalidated for this specific compound