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These dose-dependent effects include reductions in: inflammatory pathway activations proinflammatory cytokine and collagen degradation enzyme expressions mitochondrial dysfunction oxidative stress According to the above review, all three studies highlighted that GLP-1 analogs may work to treat RA by inhibiting the nuclear factor kappa-light-chain-enhancer of activated B cells pathway, which can improve immune responses

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N Engl J Med 362:16751685 Cusi K, Orsak B, Bril F et al (2016) Long-term pioglitazone treatment for patients with nonalcoholic steatohepatitis and prediabetes or type 2 diabetes mellitus: a randomized trial