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This dual mechanism is believed to explain why Tirzepatide achieves: Greater HbA1c reductions (up to 2.5%) More significant weight loss (up to 22% body weight in some studies) Ongoing Research and Implications Tirzepatides mechanism opens the door to multi-target metabolic therapya promising future direction for treating not only type 2 diabetes, but also obesity, fatty liver disease (NAFLD), and cardiovascular risks

However, further studies with more quantitative measures of ASCVD are needed to assess this possibility

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Waist circumference above 40 inches for men or 35 inches for women is associated with increased health risk and may indicate metabolic dysfunction even at lower BMI levels

The most relevant human literature is mostly about endogenous MGF expression after exercise, not controlled trials of PEG-MGF peptide therapy [2] [6]