joe rogan on semaglutide I was sent this clip with @joerogan and @billmaher talking about obesity as a disease and the new GLP-1 meds (eg wegovy and ozempic). I had to make a few comments because Frier Levitt Secures Major Litigation

In the STEP trials, adults on semaglutide (2.4 mg weekly) lost about 15% of their body weight on average

I am a proponent of using GLP-1s for weight loss when done responsibly and in a way that sets the patient up for long-term success (i.e., a healthy lifestyle that allows them to maintain their weight post-medication)

[DOI] [PMC free article] [PubMed] [Google Scholar] 69.Abdelmegeed MA, Moon KH, Hardwick JP, Gonzalez FJ, Song BJ

Moore A, Morris ID: The involvement of insulin-like growth factor-I in local control of steroidogenesis and DNA synthesis of leydig and non-leydig cells in the rat testicular interstitium

Enantiomers were separated and according to computational modeling the inhibitory capacity of the compounds were attributed to the S -configuration of the spiro-oxindole dihydroquinazolinones