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CHAC1 functions as a -glutamylcyclotransferase catalysing glutathione degradation 39

Concurrently, GSH reduces Fe 3 + to Fe 2 + , which activates S 2 O 8 2 to generate highly toxic sulfate (SO 4 ) and hydroxyl radicals, inducing coordinated ferroptosis and pyroptosis in lung cancer cells 219

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Physical Therapy Physical therapy remains the gold standard first-line treatment with strong evidence supporting eccentric loading programs