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(2023) Probability of 5% or Greater Weight Loss or BMI Reduction to Healthy Weight Among Adults With Overweight or Obesity Uchiyama, Syutaro, et al (2023) Oral Semaglutide Induces Loss of Body Fat Mass Without Affecting Muscle Mass in Patients With Type 2 Diabetes Real Science, Real Results Get expert insights on fueling your body, supporting metabolism, and living longerdelivered to your inbox every Monday

Injectable tirzepatide shows: ~1521% average weight loss up to ~26% with lifestyle changes consistent long-term outcomes Oral GLP-1 drugs, like Rybelsus, typically show: lower weight loss at standard doses need for higher dosing to match injections stricter intake conditions If oral tirzepatide eventually becomes available, it will likely require higher doses, produce slower or less pronounced weight loss and come with stricter intake instructions

PMC 7179765