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However, the use of the PRIME T2D Model, which has demonstrated positive validation results against CVOTs (including LEADER) with no calibration required, could mitigate the absence of direct inclusion of CVOT data in the present study, and this represents a key strength of the PRIME T2D Model, particularly given the previously poor results of validation exercises across type 2 diabetes models [18, 51, 52]

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For individuals with hypertension, dyslipidemia, or metabolic syndrome, medical therapy can help reduce cardiovascular strain and increase the safety margin of surgery