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In the body, about 95% of the total choline pool is converted to phosphatidylcholine, an essential component of the phospholipid bilayer and the predominant phospholipid in most mammalian cells
The 10 mg/day arm showed a smaller reduction than the 1 mg group, confirming the absence of a dose-dependent response above the threshold range
By dosage, the mean changes were: 500 mcg: 127% 750 mcg: 176% (single study) 1,000 mcg: 280% 1,500 mcg: 310% 2000 mcg: 260% 5,000 mcg: 62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways
According to the British National Formulary and NICE Clinical Knowledge Summaries, the typical regimen for patients without neurological involvement involves 1 mg injections three times weekly for two weeks, followed by maintenance injections every two to three months
The Essendon club's former sports scientist, Stephen Dank, has said he only ever injected players with vitamins that were within WADA guidelines, but he has admitted using AOD-9604 on players and claims he was advised last year by ASADA that this was legal
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