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The authors thank Professor Patricia Brubaker, Departments of Physiology and Medicine, Canada Research Chair in Vascular and Metabolic Biology, University of Toronto for critical reading of the manuscript

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Dysfunction of BMSCs reduces their osteogenic differentiation and proliferative capacity, thereby compromising osteoblast formation and contributing to age-related declines in bone formation ( Method As shown in Figure 2 , a systematic review of recent research for ferroptosis and osteoporosis was conducted using the PubMed and Embase search engines from 1 January 1, 2019 to February 20, 2025