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Another study (113) has also shown that AD can attenuate hypoxia-induced migration and invasion of RA-FLS and the expression of MMPs (MMP-1, MMP-3 and MMP-9) by inhibiting the HIF-1 signaling pathway

Endogenous antioxidant that plays a major role in reducing reactive oxygen species formed during cellular metabolism and the respiratory burst

Proc Natl Acad Sci USA 104(29):1201712022 Fernandez-Marcos PJ, Auwerx J (2011) Regulation of PGC-1, a nodal regulator of mitochondrial biogenesis

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In some embodiments, the injection is into the inner ear