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doi: 10.1016/j.cgh.2012.02.018

The increase in GH secretion precedes the reduction in IGF-I levels that is only evident by the third day of fasting, thereby ruling out the increase in GH during fasting is related to reductions in total IGF-I

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Its a targeted signal that doesnt touch the parts of growth hormone associated with side effects, and that makes it all the more promising for future studies