nejm semaglutide ckd Incidence of Chronic Kidney Disease among Adults with Diabetes, 2015–2020 New in the March 5,

Side effects, contraindications, and what to discuss with your provider before starting

Who Should Use Caution and When to Contact Your Provider Patients with a personal history of pancreatitis, medullary thyroid cancer, multiple endocrine neoplasia type 2, or severe dehydration should avoid GLP-1 therapy or use it only under close specialist supervision

Monitor your urine color as a hydration indicator

Crucially, unlike metformin, BBR exhibits a direct anti-androgenic effect by inhibiting the expression of key steroidogenic enzymes (CYP17A1, StAR) and suppressing Aldo-Keto Reductase (AKR1C3) activity in ovarian theca cells [77,78,79]

For now, there is no clear evidence that Ozempic causes flare-ups or progression of ulcerative colitis, but the lack of large-scale data means patients should proceed carefully and under close medical supervision