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The ELAD trial (Evaluating the Effects of the Novel GLP-1 Analogue Liraglutide in Alzheimers Disease) was a Phase 2b randomized, double-blind, placebo-controlled study in ~204 patients with mild AD

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This technique offers the best available ionization efficiency but is also prone to signal suppression or enhancement (SSE) due to coeluting matrix components (Matuszewski et al

They have two important attributes, which allow them to be chosen as protecting osmolytes during evolution: 1) they provide high stability for proteins against denaturation, and 2) they can accumulate at high concentrations in the cell without impeding the cellular functions (Singh et al., 2011)