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Studies in rodents have shown that BAT is not only a target for FGF-21 but also a significant source of systemic FGF-21: BAT expresses and releases FGF-21 in response to thermogenic activation, for example during cold exposure, indicating that BAT plays a role in the systemic regulation of FGF-21 [48]

REGION North America to be fastest-growing region in global biosimilars market during forecast period The North America biosimilars market is expected to register the highest CAGR during the forecast period, driven by increasing demand for cost-effective biologic therapies, a growing number of biosimilar approvals by regulatory agencies, and the expiration of patents on existing biologic products

Some sustained-release nicotinic acid (niacin) formulations have a higher incidence of hepatotoxicity when compared to immediate-release dosage forms

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Chapter 68) As shown in Figure 521, red blood cells and platelets share a common pathway of differentiation until the stage of megakaryocyte erythroid progenitors