GLP-1 receptor agonists should be considered when patients experience significant weight regain with BMI 27 kg/m with obesity-related comorbidities or BMI 30 kg/m, lifestyle modifications have been insufficient, no anatomical complications require surgical revision, and patients are willing to engage in long-term pharmacotherapy
In this study, type 2 diabetes mellitus rats were fed either a high-fat diet or a standard diet with detailed macronutrient compositions
This review is distinct from prior analyses by focusing not only on ASTs molecular mechanisms but also on its delivery challenges, bioavailability, and translational relevance
An effective pill could bring more people into treatment earlier, before obesity-related complications like diabetes, heart disease, and joint pain take hold
The efficacy of tirzepatide has generated interest in the development of further multi-receptor agonists that may provide enhanced therapeutic advantages while preserving good safety profiles (Sinha et al
