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Tips for Alcohol Use on GLP-1s Drink in moderation (no more than 1 drink/day for women, 2 for men) Avoid drinking on an empty stomach Stay hydrated with water between alcoholic beverages Avoid sugary cocktails or mixers Nutrition is Key: Support Your Body on a GLP-1 Whether youre drinking coffee or alcohol occasionally, your top priority should be proper nutrition
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Normal vital signs (blood pressure, heart rate, respiratory rate, temperature) and body mass index (BMI) between 18 and 30 kg/m 2 Suboptimal vitamin B12 status (deficient to borderline 200300 pg/mL), defined as serum B12 levels within the lower end of the reference range (234894 pg/mL) Able to provide informed written consent Able to comply with study procedures and follow-up visits as outlined in the protocol 2.2.2 Exclusion criteria Known hypersensitivity or allergy to oral vitamin B12 supplements or any of its components Known history of cobalt allergy or sensitivity Severe malabsorption syndromes, including pernicious anemia or intestinal disorders affecting vitamin B12 absorption Current use of acetaminophen, nonsteroidal anti-inflammatory drugs, antibiotics, antacids, proton pump inhibitors (PPIs), multivitamins, or nutritional supplements containing vitamin B12 History of gastric bypass surgery or other procedures that significantly alter GI anatomy or function Significant renal impairment (estimated glomerular filtration rate [eGFR] 0.05) Supplementary Table 1
We employ an optimized, dual-delivery strategy to maximize neurorestorative effects: Intrathecal Delivery: Stem cells administered directly into cerebrospinal fluid enhance access to the hypothalamus, brainstem, and SCN, targeting core sleep centers
