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doi: 10.3389/fphar.2014.00173 Received 18 April 2014 Accepted 04 July 2014 Published 22 July 2014 Volume 5 - 2014 Edited by Paolo Arosio, University of Brescia, Italy Reviewed by Constantin Ion Mircioiu, Carol Davila University of Medicine and Pharmacy, Romania

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171 Additionally, refluxed acid and bile help stabilize hypoxia-inducible factor-2 (a key transcription factor that plays a critical role in cellular and systemic responses to hypoxia) in esophageal epithelial cells

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Briefly, cells were added to 96-well plates (5 10 3 )/well and incubated in the presence of a range of PQQ concentrations (1, 5, 10, 25, 50, 100, 150, 200 M), with six replicate samples per condition

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