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A full overview of the indications of the specific treatments has been described in recent guidelines ( GLP-1 receptor agonism in heart failure Clinical evidence Only a few clinical investigations studying the effects of GLP-1 RAs specifically in HF (all in HFrEF) have been reported as briefly discussed below

The proportionally shorter break reflects the stable effects typically maintained after discontinuation

doi: 10.3945/an.112.002154

doi: 10.3390/ijms141123045 82 IshibashiYMatsuiTOjimaANishinoYNakashimaSMaedaSet al

Given the differences in the MedDRAs categorization rules, some potential PTs that were not included may exist, e.g., depression suicidal (belonging to HLGT level, depressed mood disorders and disturbances) and intentional overdose (belonging to HLGT level, overdoses, and underdoses NEC)