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Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens

However, given the significant methodological limitations of these studies, the research reviewed here does not support the use of chelation as a treatment for ASD 1 2 "Stalled trial for autism highlights dilemma of alternative treatments"

Badenhorst T, Svirskis D, Steinberg C, et al

Medina S, Martnez M, Hernanz A

Insomnia: Despite generally improving sleep, some patients report difficulties