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Keiser AA, Matazel KS, Esser MK, Feifel D, Prus AJ

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IL-4 secreted by activated T cells has anti-angiogenic effects by inhibiting VEGF production in RA FLS, which helps relieve RA ( + T cells population ( via activation of protein kinase C (PKC) / II and ERK-1/2, with concomitant down-regulation of the NF-B/p65 pathway ( via activating Smad-2/3 in RA ( ( Figure 1 )

When I met with the editor of the BNF a year or two again she told me that any change in the treatment would have been based on evidence based research