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Women of childbearing potential should be counseled on avoiding pregnancy while on MB therapy, and if a pregnant patient has a medical emergency like methemoglobinemia, the physician must weigh the maternal benefit against the fetal risk very carefully

DISCUSSION These analyses provide a robust assessment of the GI tolerability of semaglutide 2.4 mg in ~2650 adults over 68 weeks and show that weight loss with semaglutide 2.4 mg was mostly attributable to effects unrelated to GI AEs

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There is no limit for the intake of vitamin B12 because the risk of toxicity or overdoes is extremely low

Staying hydrated and not skipping meals entirely can make a real difference