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Ten studies used a dosage of less than 500 mg, seven trials used 500 to 1,000 mg, 12 used 1,000 to 2,000 mg, and 13 used 2,000 or more mg.20 A 2019 systematic review and meta-analysis of 13 randomized clinical trials found that L-carnitine supplementation was significantly associated with lower levels of C-reactive protein in comparison to controls

Safety signals: If Phase 3 trials reveal unexpected adverse events, FDA will require additional safety data, potentially delaying approval by 1-2 years

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Medical Conditions: Underlying health issues like an underactive thyroid, diabetes, heart disease, kidney disease, or even certain infections can manifest as profound fatigue