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What to supplement: Start with low doses of methylated B vitamins (e.g., 400-800mcg methylfolate, 500-1000mcg methyl-B12) Increase gradually while monitoring symptoms Include B6 and other B-complex vitamins Retest homocysteine after 2-3 months If low homocysteine is accompanied by low SAMe: If testing shows both low homocysteine and low SAMe, you may benefit from methylation support

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