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Regulatory Metal Sites Structural metal sites, like some of the FeS cluster sites described above, can also play regulatory roles in the absence of metal oxidation or reduction

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For example, GABA-synthesizing glutamic acid decarboxylase 65 ( GAD65/GAD1 ) and GABA receptor alpha 2 ( GABRA2 ) showed age-dependent increase in their DNA methylation (Siegmund et al., 2007), whereas GABA receptor alpha 1 ( GABRA1

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