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The case report of autoimmune encephalitis after tirzepatide use, while isolated, raises the question of whether GLP-1/GIP receptor agonism can occasionally trigger aberrant immune responses rather than suppress them
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A subsequent analysis from STEP-4 showed that discontinuation after 20 weeks of treatment led to regain of approximately two-thirds of lost weight within one year, which is why most Florida insurers approve ongoing therapy rather than time-limited courses 6
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