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Whats actually in there? Knoepfler said

Topical applications may show initial improvements in skin texture and hydration within 2-4 weeks, with more significant changes in collagen production and skin firmness becoming apparent after 8-12 weeks of consistent use

No human dose has been established and no human trials exist

doi:10.2174/1574886309666140605114614 Ferri: Ferri's Clinical Advisor 2013, 1st ed

Animals All mice were maintained under specific pathogen-free conditions at the Prklinisches Experimentelles Tierzentrum (PETZ), Erlangen, Germany and approved by the local ethics authorities of the Regierung of Unterfranken (#55.2-2532-2-424 and #55.2-2532-2-630)