The physiological regulation of skeletal muscle fatty acid supply and oxidation during moderate-intensity exercise
In tumors, persistent ROS elevation increases GSH synthesis and shifts the redox balance, creating a biochemical environment that selectively activates disulfide/diselenide linkers and metal-based GSH-depleting nanoplatforms
doi: 10.1038/ijo.2013.149 62 BlundellJFinlaysonGAxelsenMFlintAGibbonsCKvistTet al
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In a previous study, after blocking PD-L1, the phosphorylation levels of AKT/mTOR target protein decreased, expressions of key glycolysis enzymes were down-regulated, the inhibitory effects of T cells were weakened, and the anti-tumour effects were finally enhanced (107)