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Discussion The results of the current meta-analysis, that included 60,080 patients with T2DM, 14,804 of whom without established CV disease, demonstrate that GLP-1RA reduce the risk of MACE by 14% in the overall diabetic population, with an apparently greater effect in patients with known CV disease as compared with those without established CV disease (16% vs 6% reduction, respectively)

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Animals harboring these two base-pair mutations in the glp-1 promoter exhibited reduced GLP-1::V5 expression and PZ germ cell number to a similar extent as the motif deletion (Fig