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In a study on young, healthy, physically active adults, 1,500 mg of Nitrosigine enhanced flow-mediated dilation (FMD) nearly as much as 8,000 mg of Citrulline Malate 2:1 (~5,333 mg of L-Citrulline), demonstrating that Nitrosigine is one of the most potent and compact capsule-sized nitric oxide enhancers available [R, R, R, R]