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PMID: 31790002

Hours after the initial trigger, mast cells produce and secrete certain chemokines (TNF, CCL2, CCL8) and renin.[ref] The different mediators released can lead to different symptoms of mast cell activation syndrome: Histamine leads to headaches, migraines, low blood pressure, itching, stomach acid release (and much more) Tryptase causes inflammation and fibrinogen lysis

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[5] Patients prescribed GLP-1 agonists often have type 2 diabetes or obesity, conditions independently associated with increased rates of osteoarthritis and other musculoskeletal disorders

Jacoby, D