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Beyond purely enzymatic protection, the presence of Aib imposes severe biophysical restrictions on the backbone dihedral angles (specifically the phi and psi angles) of the peptide chain

Instead, its typically triggered by rapid weight loss, which can lead to telogen effluvium

Although half of the children experience at least one side effect, only 19% have to stop the drug (52)

De Bie MK, Ajmone Marsan N, Gaasbeek A et al (2012) Left ventricular diastolic dysfunction in dialysis patients assessed by novel speckle tracking strain rate analysis: prevalence and determinants