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Unlike semaglutide, which targets only the GLP-1 receptor, tirzepatide activates both GLP-1 and GIP receptors, producing a synergistic effect on appetite regulation, insulin sensitivity, and fat metabolism

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Research suggests glutathione helps recycle vitamin C, and alpha lipoic acid may support glutathione levels in return., Think of them as a connected system rather than a ranking

Nutrition and lifestyle interventions, particularly a personalised keto or low-carb, anti-inflammatory protocol, should always be the first-line approach for metabolic health and weight management in lipoedema

This paradox may be partially explained by the cellular source: endothelial NOS (eNOS)-derived NO appears protective, while inducible NOS (iNOS) from macrophages tends to promote fibrosis [83]