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Correspondingly, we found that the NAC treatment largely increased the number of surviving SGNs in the peroxynitrite + NAC group compared with the peroxynitrite-only group, as well as in the peroxynitrite + gpx1 / + NAC group compared with the peroxynitrite + gpx1 / group (Figure 6D)

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Furthermore, the presence of amide functionality at the S 1 site was found to be undesirable, as it resulted in very poor inhibition of the enzyme

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