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doi: 10.1016/S0140-6736(08)61206-4

Additionally, mutation of residue 809 within the S2 subunit of the RaTG13 spike protein (S809D) impaired elastase-induced cleavage and infectivity

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undernutrition states post-operative, post-infection, post-trauma, post-chemotherapy, chronic respiratory insufficiency, the elderly, the newborn prediabetics or diabetics hyperlipemia or in the treatment of heart disease (angina, heart failure), liver failure, cirrhosis