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Key Takeaways Melanotan II is a synthetic peptide that mimics alpha-melanocyte-stimulating hormone (-MSH) and activates melanocortin receptors involved in pigmentation, appetite, and sexual function

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Wegovy is contraindicated during pregnancy and should be discontinued at least 2 months before a planned pregnancy

Second, when we added medium-chain fatty acid (C8, octanoate), which can access the mitochondrial matrix largely independently of the CPT1/CPT2-mediated carnitine shuttle in the kidney and liver ( 34, 35 ), the liver and kidney of SLC25A45 KO mice were able to increase OCR at an equivalent level to control mitochondria ( Fig