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Moreover, the C-terminal serine of the peptide was replaced by cysteine via site-directed mutagenesis performed with polyethylene glycol.78 The half-life of PEG-loxenatide is approximately 1 week.123 GLP-1RAs

Given the small sample size, absence of a comparator group, heterogeneous follow-up, and limitations inherent to retrospective data collection, no conclusions regarding glycemic efficacy, cardiovascular safety, or overall safety profile can be drawn

The peptide works through pituitary stimulation, and existing pituitary pathology could affect both efficacy and safety

Isotretinoin is a second generation retinoid that is taken by mouth

If vomiting becomes frequent or you cant keep fluids down, its important to contact your healthcare provider