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At the same time, a 2025 systematic review and meta-analysis found that GLP-1 receptor agonists actually increased total testosterone, luteinizing hormone, and follicle-stimulating hormone levels in men with overweight or obesity

Downstream activation of nuclear factor-B (NF-B), activator protein-1 (AP-1) and interferon-regulatory factors induces expression of inflammatory cytokines, chemokines and type I interferons 9

These medications help regulate blood sugar and appetite levels by increasing insulin production and decreasing glucose production in the liver

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