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Accessed 2/10/2022, Lim EL, Hollingsworth KG, Aribisala BS, Chen MJ, Mathers JC, Taylor R

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Cagrilintide (Long-Acting Amylin Analog) Amino acid sequence modified from native human amylin [3] Fatty acid acylation extends half-life to approximately 7 days [2] Selective amylin receptor agonist (AMY1, AMY2, AMY3) [4] Delays gastric emptying and reduces food intake [5] Controls postprandial glucose metabolism [6] Synergistic effects with GLP-1 receptor agonists [7] CagriSema: The Synergistic Combination One of the most significant developments in cagrilintide research is its combination with semaglutide (a GLP-1 receptor agonist), known as CagriSema