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Although the precise cause is not fully understood, factors like a low-fiber diet, aging, and lack of exercise may contribute

It works by increasing insulin production and lowers glucagon secretion as well as targets areas in the brain that regulate appetite and food intake

Peripherally administrated GLP-1RA may also indirectly act on the brain by binding to GLP-1Rs on vagal afferent parasympathetic nerve endings, thereby generating and transmitting satiety signals to the hypothalamus and hindbrain (19)

Exenatide decreases hepatic fibroblast growth factor 21 resistance in non-alcoholic fatty liver disease in a mouse model of obesity and in a randomised controlled trial

They may reduce markers of inflammation in adipose tissue and could support healthier fat distribution [31]