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The compound remains at the investigational stage and its human safety profile has not been validated

Lin S, Deng Y, Huang J, Li M, Sooranna SR, Qin M, et al

Participants receiving higher doses of tirzepatide showed greater reductions in triglycerides and LDL cholesterol compared to placebo groups

Starting price is $349 per month for the 2.5 mg dose Higher doses are priced separately

To confirm that the improved response to cold was dependent on creatine, mice were treated with the creatine-depleting drug -guanidinopropionic acid (-GPA) 21 , which can only be used acutely as chronic exposure can induce weight loss 19,21