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The peptide is associated with changes in the hypothalamic-pituitary-adrenal axis, and this may play role in suicidal patients with major depressive disorder with altered DSIP-like immunoreactivity levels

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This is particularly important for gamefowl that may experience stress or changes in their environment, as it encourages them to eat properly and maintain optimal body weight

Moreover, research shows that its low levels may be linked to Alzheimer's disease and other neurodegenerative conditions