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Furthermore, infusion of Exendin-4 in NAc has been shown to attenuate alcohol self-administration and related behaviors in mice and rats 15,31

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Dec 19 2022;11(24)doi:10.3390/jcm11247524

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As oestrogen drops during perimenopause and menopause, so does this built-in protection

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These findings suggest that while FOXO4 is involved in the senescence pathway, it also plays a role in maintaining the viability of senescent Leydig cells by suppressing their apoptotic response, which could contribute to the accumulation of senescent cells [1]

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