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As most RCTs were designed to evaluate metabolic or cardiovascular outcomes rather than cancer endpoints, their follow-up periods may be insufficient to fully capture the latency of solid tumor development

Del PratoSRosenstockJGarcia-SanchezRIqbalNHansenLJohnssonEet al

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Clinicians should conduct a thorough baseline assessment including personal and family history of kidney stones, current hydration status, dietary habits, and relevant comorbidities